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KMID : 0361520070180040251
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Korean Journal of Psychopharmacology
2007 Volume.18 No. 4 p.251 ~ p.255
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Ziprasidone Induced Neutropenia
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Yang Jong-Chul
Kim Seon-Young
Park Tae-Won
Chung Young-Chul
Chung Sang-Keun
Hwang Ik-Keun
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Abstract
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Neutropenia and agranulocytosis are dangerous conditions seldom caused by antipsychotics. We report the case of a 35-year-old female patient who presented with neutropenia following ziprasidone administration. Ziprasidone was gradually increased to 160 ㎎/day in combination with escitaloprarn 10 ㎎/day. Following ziprasidone administration, her neutrophil count fell to 1700×10³/㎣, on day 45 and to 1500×10³/㎣ on day 57. Ziprasidone was immediately stopped, and quetiapine 25 ㎎ was given from the next day onward, along with the escitaloprarn. Her neutrophil count rose to 2700×10³/㎣ 2 days later, and was maintained at 2,900×10³/㎣ at 17 days after changing medication. To the best of our knowledge, this case represents the first report of ziprasidoneinduced neutropenia in Korea. Further study is necessary to determine the incidence of neutropenia and its relationship with agranulocytosis secondary to ziprasidone.
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KEYWORD
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Neutropenia, Agranulocytosis, Ziprasidone, Antipsychotics
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